We describe RosettaRemodel, a generalized framework for flexible protein design that provides a versatile and convenient interface to the Rosetta modeling suite.RosettaRemodel employs a unified interface, called a blueprint, which allows detailed control over many aspects of flexible 220.10.38.20.02.001 backbone protein design the rainbow ros moriarty calculations.RosettaRemodel allows the construction and elaboration of customized protocols for a wide range of design problems ranging from loop insertion and deletion, disulfide engineering, domain assembly, loop remodeling, motif grafting, symmetrical units, to de novo structure modeling.